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| Antunes,S.L.G.; Chimelli,L.M.; Rabello,E.T.; Valentim,V.C.; Corte-Real,S.; Sarno,E.N.; Jardim,M.R.. |
| The nerve biopsies of 11 patients with pure neuritic leprosy were submitted to routine diagnostic procedures and immunoperoxidase staining with antibodies against axonal (neurofilament, nerve growth factor receptor (NGFr), and protein gene product (PGP) 9.5) and Schwann cell (myelin basic protein, S-100 protein, and NGFr) markers. Two pairs of non-adjacent histological cross-sections of the peripheral nerve were removed for quantification. All the fascicles of the nerve were examined with a 10X-ocular and 40X-objective lens. The immunohistochemistry results were compared to the results of semithin section analysis and clinical and electroneuromyographic data. Neurofilament staining was reduced in 100% of the neuritic biopsies. NGFr positivity was also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Neurofilament protein; Nerve growth factor receptor; S-100 protein; Myelin basic protein; Gene product 9.5; Neuritic leprosy; Peripheral neuropathy. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800010 |
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| Sales,A.M.; Matos,H.J.de; Nery,J.A.C.; Duppre,N.C.; Sampaio,E.P.; Sarno,E.N.. |
| Type II reaction in leprosy, or erythema nodosum leprosum (ENL), is often characterized by severe clinical symptoms together with nerve function impairment leading to permanent disabilities. Thalidomide has been shown to be a highly effective drug for the treatment of ENL. It is, however, contraindicated for women of childbearing age due to its teratogenicity. On the other hand, pentoxifylline, used to treat hypercoagulable states, is not teratogenic and, like thalidomide, can inhibit the synthesis of tumor necrosis factor-a and other cytokines. In the present randomized double-blind clinical study we compared the effectiveness of orally administered pentoxifylline vs thalidomide in treating type II reaction in 44 patients. Daily doses of 300 mg... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Leprosy; Reactional episodes; Therapy; Pentoxifylline; Thalidomide. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200011 |
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| Galhardo,M.C.G.; Alvarenga,F.F.; Schueler,G.; Perez,M.; Morgado,M.G.; Ferreira,H.; Azevedo,L.M.S.; Sampaio,E.P.; Sarno,E.N.. |
| Dysregulation of the skin immune system (SIS) could explain the high prevalence of skin disorders in HIV+ individuals. The present study was carried out to determine whether alterations in the cell population of SIS and epidermal immunoactivation occur in the normal skin of HIV+ individuals. Forty-five biopsies were taken from the normal upper arm skin of 45 HIV+ patients and of 15 healthy controls. HIV+ individuals were divided into three categories according to their CD4 cell blood count (<200, 200-499 and ³500/µl). Hematoxylin-eosin was used to stain tissue sections for morphological analysis and immunohistochemistry was used for the evaluation of the frequency of macrophages, Langerhans cells, and CD lymphocyte subsets. In addition, semiquantitative... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Skin immune system; CD8 T cells; CD4-CD8 ratio; Langerhans cells. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500017 |
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| Moreira,A.L.; Wang,J.; Sarno,E.N.; Kaplan,G.. |
| Thalidomide has been shown to selectively inhibit TNF-<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">a</font> production in vitro by lipopolysaccharide (LPS)-stimulated monocytes. TNF-<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">a</font> has been shown to play a pivotal role in the pathophysiology of endotoxic shock. Using a mouse model of LPS-induced shock, we investigated the effects of thalidomide on the production of TNF-<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">a</font> and other cytokines and on animal survival. After injection of 100-350 µg LPS into mice, cytokines including TNF-<!-- $MVD$:face("Symbol") --><FONT FACE="Symbol">a</font>, IL-6, IL-10, IL-1ß, GM-CSF... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Endotoxic shock; Thalidomide; Cytokines; Inflammation. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000010 |
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